Int J Gastrointest Interv 2019; 8(1): 6-9  https://doi.org/10.18528/ijgii180048
Robotic surgery for liver, pancreas, and bile duct pathologies: A critical analysis and personal views
Ronald Matteotti
Department of Hepato-Biliary and Pancreatic Surgery, Jersey Shore University Medical Center, Neptune, NJ, USA
*Department of Hepato-Biliary and Pancreatic Surgery, Jersey Shore University Medical Center, 19 Davis Avenue, HOPE Tower, Neptune, NJ 07753, USA. E-mail address:ronald.matteotti@hackensackmeridian.org(R. Matteotti). ORCID: https://orcid.org/0000-0002-1238-1387
Received: December 27, 2018; Revised: January 11, 2019; Accepted: January 11, 2019; Published online: January 31, 2019.
© Society of Gastrointestinal Intervention. All rights reserved.

cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract

At the beginning of this millennium robotic surgery was launched and quickly became accepted in many surgical specialties. Initially only resection procedures were performed with a few surgical steps made towards reconstructive elements. Robotic surgery helped to overcome disadvantages seen and experienced when performing laparoscopic procedures, mainly lack of haptic feedback, lack of ‘free movement’ in the abdominal cavity and inferior visualization. Since its initiation, robotic surgery was utilized more and more in complex procedures. Its use in complex liver and pancreatic surgery is still controversial as it requires a high volume center and superb training to achieve acceptable results. Robotic surgery for hepato-pancreato-biliary disease is only performed by a few centers in the United States. A team approach is mandatory and the bed side assistant is as important as the console surgeon in achieving acceptable oncological outcome. This article aims to review the most recent literature and gives some personal views into the near future with anticipated development of this exciting technology.

Keywords: Bile duct neoplasms, Forecasting, Liver diseases, Pancreas, Robotic surgical procedures, Surgery, computer assisted
Introduction

Minimally invasive surgery has become feasible in recent years for more complex procedures. This can be attributed to better instrumentation and easier access to training courses. More sophisticated preoperative imaging has made it easier to plan resections and approach difficult target lesions. Minimally invasive surgery is definitely an acceptable alternative to open procedures for most disease sites. However, whether robotic surgery could factor into highly complex liver and pancreatic procedures from an oncological standpoint remains unclear. With three-dimensional (3D) imaging and 10-fold magnification, currently available robotic system allows for more precise dissection with less blood loss and potentially higher success rate for certain types of procedures like spleen-preserving distal pancreatectomies compared to a traditional open approach. Intrinsic disadvantages of straight laparoscopy can be overcome by the most sophisticated robotic platform currently available from Intuitive Surgery©. More platforms are currently being developed, each one targeting a specific disease site or economic niche.

Materials and Methods

We reviewed the current literature between 2010 and 2018, excluding smaller case series. A critical analysis was performed. Personal views are given.

Results

Robotic cholecystectomy (Table 1)113

With the current platform available, two major approaches are used: single site and multi-port. We reviewed the current literature and found 2,039 cases listed in the time frame we choose. There is a big discrepancy in the overall length of stay between high volume and low volume centers. In our review, we found that low volume centers had more conservative discharge strategy with significantly longer length of stay. Operative time is infrequently reported. It is greater than one hour in most series. A single site was reported in acute cholecystectomy cases. Estimated blood loss was minimal in all series.

Robotic bile duct surgery (Table 2)1416

In the current literature, we found 29 cases for review. There was only one series in the field of surgical oncology. Robotic bile duct surgery, especially when deployed for cancer in the hilum, is complex, resulting in significant morbidity with a reported blood loss of 1,360 ± 809 mL.16 Firefly technology in assessing bile duct anatomy and vascular supply is tremendously helpful. It is more and more utilized in complex procedures (Fig. 1).

Robotic liver surgery (Table 3)1723

Fully robotic surgery for liver pathologies is still in its infancy. More and more small series are getting published (Table 3). We reviewed a total of 153 cases in the literature. Blood loss and length of stay were similar when compared to open or straight laparoscopy. However, its operative time was significantly longer. Oncological margins did not seem to be compromised. Outcomes were also similar to laparoscopy. Smaller lesions and left lateral segmentectomies are ideal beginner cases.

Robotic pancreas surgery (Table 4)2432

Robotic pancreas surgery can be divided into two main groups: resection only and resection followed by reconstruction. We reviewed 364 cases across the whole spectrum of pancreatic surgery and found similar outcomes and similar fistula rates.

Discussion

As with many techniques, single site cholecystectomy has made its way into the robotic world a few years ago. The initially reported high rate of incisional site hernia when done straight laparoscopically does not seem to hold up in robotic cohorts. This might be mainly due to lessons learned from laparoscopy and improved closure techniques. Although a robotic cholecystectomy is thought to be an ideal beginner case and a case to teach residents, the surgeon controlling the arm must be aware of the significant strength these instruments translates onto the tissue or a tissue. This can result in unexpected blood loss or gallbladder rupture with bile and stone spillage.1 Single site robotic surgery should be done only by an export. It has a huge advantage over single site laparoscopy as it reduces surgeon’s stress load.1 When used for benign disease, chronic cholecystitis, or biliary dyskinesia, it has been proven to be an acceptable alternative to traditional cholecystectomy in terms of outcomes, although it is more expensive.2

When compared to single site laparoscopy, the robotic system developed with the Da Vinci Si/Xi© platform gives the surgen or a surgen a huge advantage of wristed instruments with controlled torque. This might be associated with less postoperative discomfort. When it is performed in high volume centers, it can lead to earlier discharge.

Robotic bile duct surgery is complex. Patient selection is key. It definitely has an advantage when a reconstructive element is to be considered like performing a hepaticojejunostomy given wristed instruments and micro-suturing capabilities.14,15 When performed for hilar cholangiocarcinoma, it can result in significant morbidity and mortality. Patient selection is a must. Short- and long-term oncological strategies also have to be considered.16

Robotic liver surgery is only performed in a few centers in the United States. This technology requires a dedicated team not only for preoperative planning, but also for safe performance of such highly complex procedures. More and more surgical teams are performing strict anatomical resections utilizing robotic platform to their advantage.17 Segments of the liver that are difficult to access with straight laparoscopy such as segment VII and segment VIII can now be safely resected with the help of magnification and wristed instruments if robotic system is available.18 Overall results show that the robotic approach does not compromise oncological margins. It is ‘non-inferior’ to laparoscopy or open approach, the gold standard.18 In a series of 57 patients, there was no significant difference in operative outcomes when compared to laparoscopy alone.19 Another group has demonstrated a series of 11 left lateral segmentectomies, the most straight forward liver resection, and reported inferior clinical outcomes and overall costs. They had more admissions to the surgical intensive care unit, increased rate of minor complications, and longer length of stay. This might be attributed to the utilization of a new technology and surgical teams getting familiar with perioperative algorithms rather than the robotic approach alone. When factoring in indirect costs, the robotic approach was more expensive than laparoscopy.20 Overall, in all available series for review, the consensus is that robotic liver resections are feasible, non-inferior to laparoscopy or open surgery. Its benefit lays in utilizing the technology for more complex resections where laparoscopy seems to be infeasible or very difficult. Minor liver resections like left lateral segmentectomies are deemed to be good beginner cases until the steep learning curve is surpassed.2123

Pancreatic surgery can be complex. The two complex situations a pancreatic surgeon faces are spleen preservation in distal pancreatectomies and reconstruction in pancreatic head resections. Morbidity of these procedures is quite high, especially when there is a pancreatic fistula. Spleen preservation is sometimes very difficult when using straight laparoscopy. However, it can be achieved to a higher degree using the robotic system.24 Even though some series have reported an overall increase in cost, its direct costs are less, especially when performing a distal pancreatectomy. This is mainly due to a significantly shorter length of stay in the robotic group.25 Pancreatic fistula, a feared complication, can be as high as 50% in some series. This might be due to the difference or a difference in parenchyma transection technique as well classification of these events.25 Oncological outcomes in this short series were superior regarding lymph node yield achieved and rate of negative margins. Robotic surgery has a significantly lower conversion rate than laparoscopy. It is equivalent in terms of outcomes and safety.26 The system itself with its 3D visualization and magnification allows for superior anatomical dissection around the portal/splenic vein confluence and more distally around the splenic vein itself. All small contributors to the splenic vein that could result in major bleeding can be visualized earlier and better. They can be controlled with clips, sutures, or electrocautery alone. The splenic artery is usually vessel looped at the proximal border of the pancreas. It can be traced distally very easy, controlling all small branches. Our group usually applies small cardiac clips. In 2010, one of the pioneers in robotic surgery demonstrated in his own short series of 46 patients that robotic pancreatic surgery was feasible and safe when compared to open surgery, but with added benefits of a minimally invasive approach.27 When performing a Whipple (pancreaticoduodenectomy) procedure using a minimally invasive approach, the procedure itself becomes more complex as a reconstructive element is added to that. Without superb suturing technique, blood loss and fistula rate might be unacceptably high.32 This type of procedure is only performed by a handful of surgeons nationwide. Its oncological benefits need to be proven in bigger series.

Conclusion

Robotic platform provides an ideal tool for highly complex surgeries like liver resection and pancreatectomies. This is mainly due to 3D imaging and superb magnification. This technology allows for difficult reconstructions like Whipple procedures in addition to precise resections. It not only exceeds limitations seen by traditional laparoscopy, but also exceeds patient’s expectations in terms of length of hospital stay and postoperative pain management. Reduction in pain is mainly due to ‘controlled torque’ by robotic instruments compared to ‘limited control of torque’ in straight laparoscopy. The future of this exciting technology lays in a happy marriage between sophisticated preoperative 3D planning of disease site and target lesion and intraoperative, superimposed imaging in order to obtain organ-sparing surgery. Added functional imaging like Firefly technology will become mainstream not only to identify critical anatomy, but also to determine residual disease not visible to the naked eye. As more robotic platforms are being developed for specific purposes, this technology will become more affordable and more widespread. Robotic surgery is here to stay. Once we overcome economic disparities and a market monopoly, it might replace traditional laparoscopy and become affordable for more institutions. More studies are needed to address its oncological outcomes but less so focusing on technical capabilities. Combined modality with intraoperative pathology mapping is an exciting outlook in the near future.

Conflicts of Interest

No potential conflict of interest relevant to this article was reported.

Figures
Fig. 1. Firefly exam – ‘critical view of safety’. CA, cystic artery; GB, gallbladder; CyD, cystic duct; CD, common duct.
Tables

Table 1

Robotic Cholecystectomy

Study No. of cases OR time (min) EBL (mL) Length of stay (day) Single/multiport
Grochola et al1 (2018) 60 85.5 5 1.9 Single
Balachandran et al2 (2017) 415 89.4 Minimal 1.9 Single
Pietrabissa et al3 (2012) 100 71 NR NR Single
Lee et al4 (2017) 60 86.8 NR 4.3 Single
Li et al5 (2017) 78 75.7 NR 4.35 Single
Strosberg et al6 (2017) 140 74.5 10 0 Single
van der Linden et al7 (2016) 27 81 NR NR Single
Su et al8 (2017) 51 71.30 NR 4.21 Single
Baek et al9 (2015) 925 NR NR NR Multi
Chung et al10 (2015) 70 106 NR 1.5 Single
Ayloo and Choudhury11 (2014) 31 81.96 8.3 0.3 Single
Svoboda et al12 (2015) 200 69.8 NR NR Single
Morel et al13 (2014) 82 91 NR 2.4 Single

Values are presented as number only or mean only.

OR, operating room; EBL, estimated blood loss; NR, not reported.

Table 2

Robotic Bile Duct Surgery

Study No. of cases OR time (min) EBL (mL) Length of stay (day)
Giulianotti et al14 (2018) 14 280 135 8.4
Naitoh et al15 (2015) 5 489 36 18
Xu et al16 (2016) 10 703 1,360 ± 809 16

Values are presented as number only, mean only, or mean ± standard deviation.

OR, operating room; EBL, estimated blood loss.

Table 3

Robotic Liver Surgery

Study No. of cases OR time (min) EBL (mL) Length of stay (day)
Marino et al17 (2018) 35 315 245 6.5
Magistri et al18 (2017) 22 318 328–400 5.1–6.2
Tsung et al19 (2014) 57 253 50–350 3–3.5
Packiam et al20 (2012) 11 175 30 4
Berber et al21 (2010) 9 259 136 ± 61 NR
Croner et al22 (2016) 10 321 306 7
Croner et al23 (2015) 9 312 251 6

Values are presented as number only, mean only, range, or mean ± standard deviation.

OR, operating room; EBL, estimated blood loss; NR, not reported.

Table 4

Robotic Pancreas Surgery

Study No. of cases OR time (min) EBL (mL) Length of stay (day) Fistulas (n)
Kang et al24 (2011) 20 298 372 7.18 0
Waters et al25 (2010) 17 298 279 4 NR
Daouadi et al26 (2013) 30 293 212 6.1 14
Giulianotti et al27 (2010) 46 331 323 9.3 9
Wayne et al28 (2013) 12 298 100–350 3.9 0
Vicente et al29 (2017) 50 370 NR 17.6 10
Kim et al30 (2018) 51 335.6 NR 10.6 3
Ryan et al31 (2015) 18 225 175 5 1
Kauffmann et al32 (2016) 130 521.7 ± 98.7 819.4–1,430.2 NR 37

Values are presented as number only, mean only, range, or mean ± standard deviation.

OR, operating room; EBL, estimated blood loss; NR, not reported.

References
  1. Grochola LF, Soll C, Zehnder A, Wyss R, Herzog P, Breitenstein S. Robot-assisted versus laparoscopic single-incision cholecystectomy: results of a randomized controlled trial. Surg Endosc. 2018. doi: 10.1007/s00464-018-6430-7. [Epub ahead of print]
    Pubmed CrossRef
  2. Balachandran B, Hufford TA, Mustafa T, Kochar K, Sulo S, Khorsand J. A comparative study of outcomes between single-site robotic and multi-port laparoscopic cholecystectomy: an experience from a tertiary care center. World J Surg. 2017;41:1246-53.
    Pubmed CrossRef
  3. Pietrabissa A, Sbrana F, Morelli L, Badessi F, Pugliese L, Vinci A, et al. Overcoming the challenges of single-incision cholecystectomy with robotic single-site technology. Arch Surg. 2012;147:709-14.
    Pubmed CrossRef
  4. Lee EK, Park E, Oh WO, Shin NM. Comparison of the outcomes of robotic cholecystectomy and laparoscopic cholecystectomy. Ann Surg Treat Res. 2017;93:27-34.
    Pubmed KoreaMed CrossRef
  5. Li YP, Wang SN, Lee KT. Robotic versus conventional laparoscopic cholecystectomy: a comparative study of medical resource utilization and clinical outcomes. Kaohsiung J Med Sci. 2017;33:201-6.
    Pubmed CrossRef
  6. Strosberg DS, Nguyen MC, Muscarella P, Narula VK. A retrospective comparison of robotic cholecystectomy versus laparoscopic cholecystectomy: operative outcomes and cost analysis. Surg Endosc. 2017;31:1436-41.
    Pubmed CrossRef
  7. van der Linden YT, Brenkman HJ, van der Horst S, van Grevenstein WM, van Hillegersberg R, Ruurda JP. Robotic single-port laparoscopic cholecystectomy is safe but faces technical challenges. J Laparoendosc Adv Surg Tech A. 2016;26:857-61.
    Pubmed CrossRef
  8. Su WL, Huang JW, Wang SN, Lee KT. Comparison study of clinical outcomes between single-site robotic cholecystectomy and single incision laparoscopic cholecystectomy. Asian J Surg. 2017;40:424-8.
    Pubmed CrossRef
  9. Baek NH, Li G, Kim JH, Hwang JC, Kim JH, Yoo BM, et al. Short-term surgical outcomes and experience with 925 patients undergoing robotic cholecystectomy during a 4-year period at a single institution. Hepatogastroenterology. 2015;62:573-6.
    Pubmed
  10. Chung PJ, Huang R, Policastro L, Lee R, Schwartzman A, Alfonso A, et al. Single-site robotic cholecystectomy at an inner-city academic center. JSLS. 2015;19. e2015.00033
    Pubmed KoreaMed CrossRef
  11. Ayloo S, Choudhury N. Single-site robotic cholecystectomy. JSLS. 2014;18. e2014.00266
    Pubmed KoreaMed CrossRef
  12. Svoboda S, Qaqish TR, Wilson A, Park H, Youssef Y. Robotic single-site cholecystectomy in the obese: outcomes from a single institution. Surg Obes Relat Dis. 2015;11:882-5.
    CrossRef
  13. Morel P, Buchs NC, Iranmanesh P, Pugin F, Buehler L, Azagury DE, et al. Robotic single-site cholecystectomy. J Hepatobiliary Pancreat Sci. 2014;21:18-25.
    Pubmed CrossRef
  14. Giulianotti PC, Quadri P, Durgam S, Bianco FM. Reconstruction/repair of iatrogenic biliary injuries: is the robot offering a new option? Short clinical report. Ann Surg. 2018;267:e7-9.
    Pubmed CrossRef
  15. Naitoh T, Morikawa T, Tanaka N, Aoki T, Ohtsuka H, Okada T, et al. Early experience of robotic surgery for type I congenital dilatation of the bile duct. J Robot Surg. 2015;9:143-8.
    Pubmed CrossRef
  16. Xu Y, Wang H, Ji W, Tang M, Li H, Leng J, et al. Robotic radical resection for hilar cholangiocarcinoma: perioperative and long-term outcomes of an initial series. Surg Endosc. 2016;30:3060-70.
    Pubmed CrossRef
  17. Marino MV, Gulotta G, Komorowski AL. Fully robotic left hepatectomy for malignant tumor: technique and initial results. Updates Surg. 2018. doi: 10.1007/ s13304-018-0560-2. [Epub ahead of print]
    Pubmed CrossRef
  18. Magistri P, Tarantino G, Guidetti C, Assirati G, Olivieri T, Ballarin R, et al. Laparoscopic versus robotic surgery for hepatocellular carcinoma: the first 46 consecutive cases. J Surg Res. 2017;217:92-9.
    Pubmed CrossRef
  19. Tsung A, Geller DA, Sukato DC, Sabbaghian S, Tohme S, Steel J, et al. Robotic versus laparoscopic hepatectomy: a matched comparison. Ann Surg. 2014;259:549-55.
    Pubmed CrossRef
  20. Packiam V, Bartlett DL, Tohme S, Reddy S, Marsh JW, Geller DA, et al. Minimally invasive liver resection: robotic versus laparoscopic left lateral sectionectomy. J Gastrointest Surg. 2012;16:2233-8.
    Pubmed KoreaMed CrossRef
  21. Berber E, Akyildiz HY, Aucejo F, Gunasekaran G, Chalikonda S, Fung J. Robotic versus laparoscopic resection of liver tumours. HPB (Oxford). 2010;12:583-6.
    Pubmed KoreaMed CrossRef
  22. Croner RS, Perrakis A, Hohenberger W, Brunner M. Robotic liver surgery for minor hepatic resections: a comparison with laparoscopic and open standard procedures. Langenbecks Arch Surg. 2016;401:707-14.
    Pubmed CrossRef
  23. Croner RS, Perrakis A, Brunner M, Matzel KE, Hohenberger W. Pioneering robotic liver surgery in Germany: first experiences with liver malignancies. Front Surg. 2015;2:18.
    Pubmed KoreaMed CrossRef
  24. Kang CM, Kim DH, Lee WJ, Chi HS. Conventional laparoscopic and robot-assisted spleen-preserving pancreatectomy: does da Vinci have clinical advantages?. Surg Endosc. 2011;25:2004-9.
    Pubmed CrossRef
  25. Waters JA, Canal DF, Wiebke EA, Dumas RP, Beane JD, Aguilar-Saavedra JR, et al. Robotic distal pancreatectomy: cost effective?. Surgery. 2010;148:814-23.
    Pubmed CrossRef
  26. Daouadi M, Zureikat AH, Zenati MS, Choudry H, Tsung A, Bartlett DL, et al. Robot-assisted minimally invasive distal pancreatectomy is superior to the laparoscopic technique. Ann Surg. 2013;257:128-32.
    Pubmed CrossRef
  27. Giulianotti PC, Sbrana F, Bianco FM, Elli EF, Shah G, Addeo P, et al. Robot-assisted laparoscopic pancreatic surgery: single-surgeon experience. Surg Endosc. 2010;24:1646-57.
    Pubmed CrossRef
  28. Wayne M, Steele J, Iskandar M, Cooperman A. Robotic pancreatic surgery is no substitute for experience and clinical judgment: an initial experience and literature review. World J Surg Oncol. 2013;11:160.
    Pubmed KoreaMed CrossRef
  29. Vicente E, Quijano Y, Ielpo B, Duran H, Diaz E, Fabra I, et al. Role of robotic-assisted pancreatic surgery: lessons learned from our initial experience. Hepatobiliary Pancreat Dis Int. 2017;16:652-8.
    Pubmed CrossRef
  30. Kim HS, Han Y, Kang JS, Kim H, Kim JR, Koon W, et al. Comparison of surgical outcomes between open and robot-assisted minimally invasive pancreaticoduodenectomy. J Hepatobiliary Pancreat Sci. 2018;25:142-9.
    Pubmed CrossRef
  31. Ryan CE, Ross SB, Sukharamwala PB, Sadowitz BD, Wood TW, Rosemurgy AS. Distal pancreatectomy and splenectomy: a robotic or LESS approach. JSLS. 2015;19. e2014.00246
    Pubmed KoreaMed CrossRef
  32. Kauffmann EF, Napoli N, Menonna F, Vistoli F, Amorese G, Campani D, et al. Robotic pancreatoduodenectomy with vascular resection. Langenbecks Arch Surg. 2016;401:1111-22.
    Pubmed CrossRef


This Article


Cited By Articles
  • CrossRef (0)

Services
Social Network Service

e-submission

Archives