pISSN 2636-0004eISSN 2636-0012
pISSN 2636-0004Summary of the Results of Systematic Reviews on Clinical Outcomes of Peroral Endoscopic Myotomy (POEM)
| Author | Search period | Studies included | No. of cases | POEM operative time (min) |
Clinical success | Complication (%) | Mean follow-up duration (mo) | GERD (%) |
|---|---|---|---|---|---|---|---|---|
| Barbieri et al (2015)21 | 2010–2013 | 16 | 551 | 156 (42–112) | 93% as defined by clinically relevant improvement in dysphagia | Adverse event (14) | 6 | 13 |
| Talukdar et al (2015)22 | 2005–2014 | 19 | 1,045 | NA | Significant reduction in Eckardt score overall effect size (Z) of –7.95 ( |
Bleeding (1.0) | 6.5 | 10.9 |
| Mediastinal emphysema (5.2) | ||||||||
| Perforation (2.3) | ||||||||
| Pleural effusion (17.4) | ||||||||
| Pneumonia (9.9) | ||||||||
| Pneumoperitoneum (16.2) | ||||||||
| Pneumothorax (8.7) | ||||||||
| Subcutaneous emphysema (21.8) | ||||||||
| Akintoye et al (2016)23 | Up to 2014 | 27 | 1,733 | 88 ± 6 | 97% as defined by Eckardt score < 3 | Bleeding (0.6) | 8.8 | 15 |
| Esophageal perforation (0.3) | ||||||||
| Mucosal injury (9.4) | ||||||||
| Pleural effusion (9.5) | ||||||||
| Pneumoperitoneum (13) | ||||||||
| Pneumothorax (5.4) | ||||||||
| Subcutaneous emphysema (11) | ||||||||
| Crespin et al (2017)24 | Up to February 2015 | 19 | 1,310 | NA | 89.4% defined as Eckardt score < 3 in all studies except one using Eckardt score < 4 | Mucosal perforation (9.0) | 11.1 | NA |
| Pleural effusion (10.1) | ||||||||
| Pneumonia (7.9) | ||||||||
| Pneumoperitoneum (16.9) | ||||||||
| Pneumomediastinum (4.4) | ||||||||
| Pneumothorax (5.3) | ||||||||
| Subcutaneous emphysema (10.0) | ||||||||
| Andolfi and Fisichella (2019)25 | 2008–2018 | 20 | 449 | NA | 95.8% defined by relevant clinical improvement of dysphagia | NA | 20.9 | NA |
| Li et al (2019)26 | Up to November 2017 | 10 | 373 | 66.7 (17.9–220) | 92.9% defined as Eckardt score ≤ 3 | Mediastinal emphysema (5.6) | 30.0 | 10.2 |
| Mucosal perforation (7.2) | ||||||||
| Pneumothorax (1.9) | ||||||||
| Pneumoperitoneum (5.6) | ||||||||
| Subcutaneous emphysema (4.0) | ||||||||
| Others (4.0) |
GERD, gastroesophageal reflux disease; NA, not available.
*Values are presented as median (range) or mean ± standard deviation.