Risk Factors for Adverse Events during TSE
Patient related |
Elderly patient with co-morbidities |
American Society of Anesthesiologist classification grade 3–4 |
Patients on antithrombotics |
Disease related |
Achalasia cardia |
Unhealthy mucosa (stasis esophagitis) during POEM |
Sigmoid esophagus |
Prior treatment (Heller’s myotomy, balloon dilatation) |
Lots of food residue in esophagus (risk of aspiration) |
Esophageal candidiasis |
Subepithelial tumor |
Large size of tumor (> 3 cm), irregular shape |
Tumor originating from muscularis propria |
Cardia tumor |
Extraluminal tumor |
Gastroparesis |
Scarring or ulceration in antrum |
Diverticula |
Large size of diverticula |
Diverticula associated with motility disorder |
Procedure related |
Use of air for insufflation |
Incorrect electrosurgical settings (other than spray coagulation) |
Continuous large/heavy burst of current during tunneling or myotomy |
Knife (without water jet facility) |
STER of two synchronous lesions |
Unable to localize the lesion during STER and pyloric sphincter during G-POEM |
Operator related |
Long operative time |
During learning curve |
TSE, third space endoscopy; POEM, peroral endoscopic myotomy; STER, submucosal tunnelling endoscopic resection; G-POEM, gastric POEM.