Summary of Representative Published Data on EUS-Guided Ethanol Ablation for Neuroendocrine Tumors
Study | No. of patients | Indication | Size (mm) |
Needle (gauge) | Ethanol (%) | Session | Result | Adverse events |
---|---|---|---|---|---|---|---|---|
Jürgensen et al9 (2006) | 1 | Insulinoma | 13 | 22 | 95 | 1 | No recurrence at 34 mo | Mild pancreatitis |
Muscatiello et al10 (2008) | 1 | 2 nonfunctional NET | 7, 11 | NA | 40 | 2 | No recurrence at 18 mo | Necrotizing pancreatitis |
Deprez et al11 (2008) | 1 | Insulinoma | NA | NA | 98 | 1 | No recurrence at 24 mo | Mild pancreatitis, duodenal wall hematoma and ulceration |
Vleggaar et al12 (2011) | 1 | Insulinoma | 9 | 25 | 96 | 1 | Decreased size, asymptomatic at 6 mo | None |
Levy et al13 (2012) | 5 | Insulinoma | 8, 16, 18, 20, 21 | 22, 25 | 95, 98, 99 | 2 ( |
3 asymptomatic, 2 improved symptoms | None |
Qin et al14 (2014) | 4 | Insulinoma | 5.4, 10, 10, 11.8 | 25 | 95 | 1 | 4 asymptomatic | None |
Park et al15 (2015) | 11 | 10 nonfunctional NET, 4 insulinoma | 12.3 (8–19) | 22 | 99 | 1 ( |
9 complete response, 4 partial response, 1 excluded | Mild pancreatitis, pancreatic duct stricture |
de Sousa Lages et al16 (2017) | 1 | Insulinoma | 12 | NA | 95 | 1 | 1 asymptomatic | None |
EUS, endoscopic ultrasound; NET, neuroendocrine tumor; NA, not available.
*Number or mean (range).