Fig. 2. Histologic findings of the laterally spreading tumor. (A) Endoscopically biopsied specimen showing high-degree atypia (arrow), normal colonic mucosa and tubulovillous change (arrowhead) (H&E stain, ×10). (B) A leaf-like villous projections of dysplastic epithelium, the dysplastic tissue occupies less than 75% of the polyp area. Normal colonic mucosa is also seen (H&E stain, ×100). (C) High-grade dysplasia with significant nuclear pleomorphism (variation in shape/size), cribriform (arrow), loss of polarity and many mitoses is seen (H&E stain, ×200).
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