Diagnosis and management of ectopic varices

Nabeel M. Akhter; Ziv J. Haskal

doi:10.1016/j.gii.2012.08.001

pISSN 2636-0004 eISSN 2636-0012

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Gastrointestinal Intervention 2012; 1(1): 3-10

Published online December 30, 2012 https://doi.org/10.1016/j.gii.2012.08.001

Diagnosis and management of ectopic varices

Nabeel M. Akhter, and Ziv J. Haskal^*

University of Maryland School of Medicine, Baltimore, MD, United States

Correspondence to:^*Corresponding author. Division of Vascular and Interventional Radiology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, United States., E-mail address:Haskal@gmail.com (Z.J. Haskal).

Received: July 14, 2012; Accepted: July 31, 2012

Abstract

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Abstract
Introduction
Prevalence
Etiology and pathogenesis
Presentation and diagnosis
Specific anatomic locations
Management
Conclusion
Figure
References

Ectopic varices are large portosystemic collaterals in locations other than the gastroesophageal region. They account for up to 5% of all variceal bleeding; however, hemorrhage can be massive with mortality reaching up to 40%. Given their sporadic nature, literature is limited to case reports, small case series and reviews, without guidelines on management. As the source of bleeding can be obscure, the physician managing such a patient needs to establish diagnosis early. Multislice computed tomography with contrast and reformatted images is a rapid and validated modality in establishing diagnosis. Further management is dictated by location, underlying cause of ectopic varices and available expertise. Therapeutic options may include double balloon enteroscopy, transcatheter embolization or sclerotherapy, with or without portosystemic decompression, i.e., transjugular intrahepatic portosystemic shunts. In this article we review the prevalence, etiopathogenesis, anatomy, presentation, and diagnosis of ectopic varices with emphasis on recent advances in management.

Keywords: Balloon-occluded retrograde transvenous obliteration, Ectopic varices, Portal hypertension, Percutaneous embolization, Transjugular intrahepatic portosystemic shunt

Introduction

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Abstract
Introduction
Prevalence
Etiology and pathogenesis
Presentation and diagnosis
Specific anatomic locations
Management
Conclusion
Figure
References

The term “ectopic varices” has historically been used to describe abnormally dilated veins associated with gastrointestinal mucosa with propensity for gastrointestinal hemorrhage, and it has also been loosely used for portosystemic collaterals in the abdominal wall and retroperitoneum. Ectopic varices may be best defined as large pressurized portosystemic venous collaterals occurring anywhere in the abdomen except in the gastroesophageal region.^1,2

Ectopic varices account for up to 5% of all variceal bleeding.³ They may be present in duodenum, jejunum, ileum, colon, anorectum, peristomal, biliary, peritoneal, retroperitoneal, umbilical, urinary bladder, uterine, ovaries, and other locations.

Prevalence

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Abstract
Introduction
Prevalence
Etiology and pathogenesis
Presentation and diagnosis
Specific anatomic locations
Management
Conclusion
Figure
References

In a review of 169 cases of bleeding ectopic varices, 26% bled from peristomal varices,17% from duodenal,17% from jejunal and ileal,14% from colonic, 9% from peritoneal, 8% rectal, and a few from infrequent sites such as the ovary and vagina.¹ A study of 37 patients with liver cirrhosis who underwent capsule endoscopy, 8.1% were found to have small bowel varices.⁴ One 1968 angiographic study of patients with portal hypertension demonstrated an unusually high rate of paraduodenal varices, in 46 out of 106 (40%) patients; this likely described all regional venous collaterals, and not solely submucosal duodenal varices.⁵ Anorectal varices have been reported in approximately 44% of patients with cirrhosis,⁶ although only a fraction become symptomatic. Thus, true incidences are likely subject to reporting bias and the modality used for diagnosis and only a fraction of diagnosed ectopic varices are likely to become symptomatic.

Etiology and pathogenesis

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Abstract
Introduction
Prevalence
Etiology and pathogenesis
Presentation and diagnosis
Specific anatomic locations
Management
Conclusion
Figure
References

Ectopic varices represent natural portosystemic shunts secondary to portal hypertension. These collaterals occur where the portal venous system is in juxtaposition to the systemic venous system. Under normal circumstances the resistance within these collaterals is high, while it is low in the portal venous system. With the development of intrahepatic portal hypertension, these shunts act to divert flow from the increased intrahepatic vascular resistance. Surgical literature and cadaveric studies have shown portosystemic communications via (a) gastroesophageal plexus to azygous-coronary system, (b) hemorrhoidal plexus, (c) recanalized umbilical vein, and (d) pancreatoduodenal venous arcade to inferior vena cava through retroperitoneal veins of Retzius. Most reported cases of hemorrhage from ectopic varices in the West are associated with intrahepatic portal hypertension in contrast to extrahepatic portal hypertension, because of low prevalence of the latter. Prior abdominal surgery predisposes patients with portal hypertension to develop varices in unusual locations, like urinary bladder, ovaries and bare area of the liver due to adhesions.^1,2,7 Finally, ectopic varices can develop in the absence of portal hypertension due to congenital anomalous portosystemic anastomoses,⁸ abnormal vessel structures,⁹ arteriovenous fistulae,¹⁰ rare familial conditions,¹¹ or related to thromboses.¹²

Wall tension in all varices is a recognized risk factor for rupture. Per LaPlace’s law it is proportional to transmural pressure across the vessel wall and the radius of the vessel. Hence, portal pressure and vessel size are determinants of ectopic variceal hemorrhage.¹³ In our and others’ experience ectopic varices, like gastric varices may bleed at a portosystemic gradient of less than 12 mmHg.^14,15 emphasizing the need for different transcatheter treatments then those used for bleeding esophageal varices.

Presentation and diagnosis

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Abstract
Introduction
Prevalence
Etiology and pathogenesis
Presentation and diagnosis
Specific anatomic locations
Management
Conclusion
Figure
References

Ectopic varices present in a multitude of ways. For example, duodenal varices may manifest with mild or massive hematemesis or lower gastrointestinal bleeding.¹⁶ Intestinal varices distal to duodenum, usually present with hematochezia, melena, or intraperitoneal bleeding.¹⁷–¹⁹ Urinary bladder varices may present with hematuria,²⁰ and biliary varices with biliary obstruction,²¹ or rarely hemobilia and gastrointestinal bleeding.²² Ruptured varices at the right diaphragm can cause hemothoraces and dyspnea.²³ Abdominal wall varices (e.g., umbilical) can rupture externally or internally, whereas those located around the falciform ligament, diaphragm, splenic ligament or in the rectovesical region may rupture into the peritoneal cavity, leading to occult, potentially fatal intraperitoneal hemorrhage.^19,23,24

Brisk upper gastrointestinal bleeding and hematochezia should be first evaluated with emergency upper gastrointestinal endoscopy. If this fails to define an acute source of hemorrhage, intravenous contrast enhanced computed tomography (CT) may be preferable to colonoscopy (in the unprepped acute setting). Thus, presence of ectopic varices should be strongly considered in patients with known liver disease or stigmata of portal hypertension, particularly when both upper and lower endoscopies fail to identify a source of bleeding.² Elective capsule endoscopy has been successful in detecting jejunal and small bowel varices,^4,25 although its role in acute bleeding is small. Similarly, double balloon enteroscopy or push enteroscopy has the potential to visualize the greater small bowel and allow intervention.^3,26 Endoscopic ultrasound has been reported for the hemodynamic assessment of rectal²⁷ and biliary varices.²⁸

Color Doppler ultrasound has shown its value in the diagnosis of umbilical (Fig. 1A and D), duodenal,²⁹ rectal,³⁰ gall bladder,²¹ and choledochal varices.³¹ However, intravenous contrast enhanced multislice CT (Fig. 2A and B), should be considered the primary modality for diagnosis of ectopic varices, given the rapid and ubiquitous availability. CT, CT angiography, and CT enteroclysis have all been used for successful diagnosis of duodenal^32,33 and colonic varices.³⁴ While technetium TC-99m red blood cell scintigraphy has been used,³⁵ its modern role in this setting is appropriately diminishing. Finally, contrast-enhanced three-dimensional magnetic resonance (MR) angiography³⁶ can equally outline unusual portosystemic collaterals, but has little role in the acute setting. Of note, barium studies of the colon or small bowel may misdiagnose ectopic varices as polyps or tumors,¹¹ emphasizing the importance of tomographic imaging and clinical suspicion.

Specific anatomic locations

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Abstract
Introduction
Prevalence
Etiology and pathogenesis
Presentation and diagnosis
Specific anatomic locations
Management
Conclusion
Figure
References

Duodenal varices

Cirrhosis is the most commonly associated cause of duodenal varices, accounting for 30% of the cases,³⁷ but causes vary and include portal venous thrombosis and obstruction of the splenic vein and inferior vena cava.^38,39 Duodenal varices have also developed after band ligation of esophageal varices, presumably as alternate sites of spontaneous portosystemic shunting.⁴⁰ These varices are formed by the collateral veins originating from the portal vein trunk or superior mesenteric vein draining into the inferior vena cava through retroperitoneal veins of Retzius.⁴¹ Duodenal variceal rupture can lead to severe hemorrhage, with mortality as high as 40% from initial bleeding.⁴²

Jejunal, ileal, colonic, and anorectal varices

Small bowel varices are commonly seen in patients with intrahepatic portal hypertension who have previously undergone abdominal surgery. Adhesions bring the parietal surface of the viscera in contact with the abdominal wall, and portal hypertension results in formation of varices below the intestinal mucosa.⁷ A triad of portal hypertension, hematochezia without hematemesis and prior abdominal surgery characterize hemorrhage from small intestinal varices.⁴³ These varices most commonly flow into systemic circulation through the gonadal veins, and less commonly through branches of the internal iliac veins.

Rectal varices are distinguished from hemorrhoids by their typical presence above the dentate line. The differentiation of hemorrhoids and anorectal varices is an important one. Anal varices collapse with digital pressure, whereas hemorrhoids do not; of note, the prevalence of hemorrhoids in patients with liver disease is not higher than in the general population.⁶ These varices represent a portosystemic collateral pathway between the superior rectal veins of the inferior mesenteric system to the middle and inferior rectal veins of the iliac system (Fig. 3). They can be present with mild or uncontrolled hematochezia.⁴⁴ The most common colonic sites are the cecum (Fig. 2C) and rectum,⁴⁵ although isolated colonic varices, in the authors experience, rank among the rarest.

Stomal varices

Ectopic stomal varices refer to abnormally dilated veins that have developed in the stomal mucosa, often recognized by a purplish hue around the stoma.² They are common in patients with intrahepatic portal hypertension secondary to primary sclerosing cholangitis,⁷ and are frequently seen in patients with ileostomies after proctocolectomy for inflammatory bowel disease associated with primary sclerosing cholangitis (Fig. 4A).⁴⁶ The mechanism of stomal variceal hemorrhage is related to local trauma and variceal erosion.¹⁸ The overall morbidity is high, given the propensity for recurrent bleeding requiring multiple blood transfusions but mortality is low, between 3% and 4%,⁴⁷ because of the ability to institute local measures such as pressure dressing, epinephrine soaked gauze, gel foam packing, and suture ligation. These therapies are however, not effective in preventing recurrent bleeding.⁴⁸ Importantly, stomal varices can be missed by endoscopy, emphasizing the need for clinical suspicion and CT imaging in occult cases.

Biliary tract varices

In extrahepatic portal vein thrombosis, gall bladder and common bile duct varices can occur in as many as 30% of patients.²¹ They maybe an incidental finding or present with biliary obstruction secondary to mass effect on extrahepatic bile ducts.³¹ The appearance of biliary tree, by direct endoscopic retrograde cholangiopancreatography may mimic that of primary sclerosing cholangitis, and is termed as pseudosclerosing cholangitis.²¹ Rarely, biliary varices can lead to hemobilia or even catastrophic hemorrhage.²²

Vesical varices and other unusual sites

The urinary bladder wall is an unusual collateral route for venous splanchnic blood flow and these varices may develop after abdominal surgery secondary to adhesions.⁷ Bleeding from vesical varices is a rare event in patients with portal hypertension and an unusual cause of hematuria²⁰; however, due to intraperitoneal hemorrhage, this can be catastrophic.¹⁹

Other more unusual sites include right diaphragm,²³ splenorenal ligament,²⁴ splenoparametrial,⁴⁹ adnexal,⁵⁰ vaginal,⁵¹ umbilical (Fig. 1),⁵² and cutaneous varices⁵³ leading to unusual manifestations like pleural effusion, dyspnea, hematuria, and percutaneous exsanguination.

Management

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Abstract
Introduction
Prevalence
Etiology and pathogenesis
Presentation and diagnosis
Specific anatomic locations
Management
Conclusion
Figure
References

There are no randomized trials or set guidelines that dictate the management of bleeding ectopic varices. The management depends upon location of hemorrhage, presentation, local physician expertise, and the underlying causes of portal hypertension. A multidisciplinary team approach is in order, with input from intensivists, gastroenterologists, interventional radiologists, and surgeons. The medical management of variceal hemorrhage is discussed in other texts and we will confine our discussion to interventional management.

Endoscopic interventional procedures

Many ectopic varices are within reach of standard endoscopy,⁷ and, with the advent of double balloon or push enteroscopy, the reach has extended even further.²⁶ The options include endoscopic band ligation (EBL) and endoscopic injection sclerotherapy (EIS) with different agents including N-butyl-2-cyanoacrylate (NBCA), thrombin or other sclerosants. EBL was found to be superior to EIS for the treatment of esophageal varices, on the basis of lower rebleeding rate, mortality, complications, speed of application, and the need for fewer endoscopic treatments; however, the main disadvantage remains the observed higher rate of variceal recurrence in comparison to sclerotherapy. Sclerotherapy on the other hand may lead to deep ulceration, which can lead to rebleeding, stricture formation, or perforation.^54,55 Combination of two in the form of endoscopic scleroligation (ESL), has shown to be superior with decreased recurrence rates.⁵⁶ No set protocol exists for the use of above mentioned modalities for the management of ectopic varices and the choice is often situation and expertise dependent.

Endoscopic band ligation and sclerotherapy have been successfully used solo or in combination with each other and other interventional radiological modalities in controlling hemorrhage from duodenal,^57,58 jejunal,²⁶ colonic,⁵⁹ anorectal,⁶⁰ and stomal varices.⁶¹

Interventional radiological procedures

Multiple image-guided approaches to management of ectopic varices have been extensively reported. They include direct percutaneous access to varices, antegrade and retrograde sclerotherapy and/or embolotherapy, and portosystemic shunts. Transjugular and transhepatic as well as retrograde transjugular or transfemoral venous approaches have been proven useful.

Transjugular intrahepatic portosystemic shunts (TIPS)

Many publications have emphasized the role of TIPS in the management of bleeding ectopic varices in cirrhotics caused by intrahepatic portal hypertension.^14,42,62 TIPS have proven more effective in preventing recurrent esophageal variceal rebleeding than endoscopic therapy.^63,64 It has been shown that a >50% reduction in pressure gradient protected patients from rebleeding and even a reduction between 25% and 50% was also effective, with a probability of rebleeding of only 7% and less risk of encephalopathy and liver failure.⁶⁵ The portosystemic gradient thresholds for adequate ectopic varix decompression are not those oft-quoted for esophageal varices (12 mmHg). As ectopic varices decompress through varied pathways other then the coronary–azygous system, procedural endpoints must be individualized. In the authors’ experience, endoscopically verified selective decompression of esophageal, but not gastric varices can occur at 12 mmHg—the same phenomenon holds for ectopic varices, emphasizing the need for routine definitive embolization or sclerotherapy in cases where TIPS are created. While TIPS provide a primary intervention or salvage modality in duodenal,⁴² small bowel,⁶⁶ colonic (Fig. 2D and E),⁶⁶ anorectal (Fig. 3),⁶⁷ stomal (Fig. 4A and B),⁶⁸ urinary,⁶⁹ umbilical (Fig.1B and C), and cutaneous⁷⁰ variceal hemorrhage, the need for concomitant embolization must be emphasized. In bleeding ectopic varices, TIPS with embolization was superior with only two out of seven patients presenting with rebleeding in comparison to five out of 12 patients that had TIPS only without initial embolization.⁶² The decision to use a TIPS-approach depends upon local expertise, and the severity of underlying liver disease and comorbidities (e.g., Model of End Stage Liver Disease (MELD) score, encephalopathy, ischemic liver disease). Finally, shunts can be reduced or even reversed should portal decompression prove excessive.

Balloon occluded retrograde transvenous obliteration (B-RTO)

As opposed to TIPS, which is a shunt creation procedure, B-RTO is a shunt occlusion procedure. Further, it uses a retrograde rather than antegrade approach. This technique has been employed for control of gastric variceal bleeding, with success rates reaching 89%,⁷¹ without detriment in hepatic function or in hepatic encephalopathy. However, since increased portal pressure is not addressed by this procedure, there is a risk of increased pressure and bleeding from varices that have not been sclerosed and are at other sites, or development of ascites. Aggravation of esophageal varices is recognized after B-RTO of gastric varices.⁷² To forego or salvage bleeding from varices after B-RTO, different procedures have been utilized, including TIPS,⁷³ percutaneous obliteration,⁷⁴ and endoscopic interventions.⁵⁷ While largely used for primary prophylaxis of gastric varices in the East, increasing case reports have described its successful role in treatment of varices within the duodenum,^57,75 small bowel,⁷⁶ colon,⁷⁷ stoma,⁷⁸ and mesentery.⁷⁹

Percutaneous embolization

Percutaneous embolization has been widely reported using a transhepatic approach. While, successful embolization rates reach 80%, up to 65% rebleeding rate within 5 months have been described.⁸⁰ The earlier use of this approach largely predates the routine role of TIPS for other indications. The transhepatic route may provide more rapid access to portal system for some less-experienced operators; however, its added risks include transhepatic tract bleeding, recurrent hemorrhage due to lack of secondary portal decompression, and added contraindications in ascites patients. Certainly embolization is important for durable control of varices.⁸¹ In cases where decompression is contraindicated, a transjugular approach (without shunt creation) can still provide direct access to the varices. In some cases, portal hypertension leading to varices may be wholly due to extrahepatic obstruction, e.g., after Whipple or similar surgeries. Correction of portal vein stenoses or thromboses with stents may provide adequate decompression and restore hepatopetal flow.⁸² Finally, more recent case reports have described direct, ultrasound guided abdominal wall,⁵² or stomal variceal,⁸³ puncture, and sclerotherapy or coil embolization. Percutaneous embolization by itself or in association with other interventional modalities has been reported for management of hemorrhage from ectopic varices in duodenum,⁸⁴ small bowel,^25,82 anorectum,⁸⁵ stoma,^47,81,83 mesentery,⁸⁶ umbilicus,⁵² and urinary bladder.⁸⁷

Surgical interventions

The role of surgery in the modern management of ectopic varices has naturally lessened, as the operative morbidity and mortality in bleeding patients with liver disease is high. Surgery may be considered a salvage option in select patients when endoscopic and interventional radiological procedures have failed. Although distal splenorenal shunts and small diameter portocaval shunts carry less risk of encephalopathy and hepatic failure,⁸⁸ than mesocaval or portocaval shunts, they are rarely performed in acute settings. Devascularization procedures may have a small role, may not require long segment resections and can be done in patients with portal venous thrombosis, but they still require great expertise and carry high morbidity and mortality rates.⁸⁹ Other unusual shunts include double selective shunting for esophagogastric and rectal varices and utilization of large collateral vessels for nonconventional portosystemic shunt creation in children with portal venous thrombosis.^90,91 Surgery has been used for dearterialization of bleeding duodenal varices,⁹² enterectomy for bleeding ileal varices,⁹³ resection and anastomosis for colorectal varices,⁹⁴ and stapled anoplasty for anorectal varices.⁹⁵

Conclusion

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Abstract
Introduction
Prevalence
Etiology and pathogenesis
Presentation and diagnosis
Specific anatomic locations
Management
Conclusion
Figure
References

No randomized studies exist to guide the best management of ectopic varices; the bulk of knowledge comes from case reports and small retrospective case series. It is clear that many approaches have value in each specific case. Regardless of the approach, it is important to emphasize that complete obliteration and embolization of the target varix (as with BRTO) is preferable for preventing recurrent symptoms over focal embolization of feeding veins, which can allow new collateral channels to develop.^56,62,96,97 The need for portal decompression should be approached on a case-by-case basis, taking into account liver function, the presence of encephalopathy, and other concomitant complications of portal hypertension.^42,57,73,74

In conclusion, physicians need a high clinical index of suspicion to make the diagnosis of ectopic varices, and be especially vigilant in patients with liverdisease, as bleeding ectopic varices may be the first manifestation of underlying portal hypertension. Given the varied locations and complex manifestations, a multimodality approach is needed, with input from gastroenterologists, interventional radiologists and surgeons. Early diagnosis is imperative, and if endoscopy fails to reveal a source, contrast enhanced CT is strongly recommended. Interventional radiological procedures using TIPS and B-RTO approaches may offer definitive therapies in combination with endoscopic approaches.

Figures

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Abstract
Introduction
Prevalence
Etiology and pathogenesis
Presentation and diagnosis
Specific anatomic locations
Management
Conclusion
Figure
References

Fig. 1. A 53-year-old female with history of alcoholic cirrhosis transferred from outside the hospital with external bleeding around the umbilicus from cutaneous varices. (A) Preprocedure color Doppler ultrasound in periumbilical region shows flow in varices (white arrow); (B) digital subtraction image DSA from the transjugular intrahepatic portosystemic shunt (TIPS) procedure during the initial portogram shows the left portal vein (white arrow), with retrograde flow in the recanalized umbilical vein (black arrows), leading to large periumbilical varices (lowest black arrow). Initial portosystemic gradient: 21 mmHg; (C) portogram after TIPS and embolization of umbilical vein varix with liquid embolic agent (Onyx, ev3 Endovascular, Inc. Plymouth, MN. USA), shows antegrade flow without retrograde filling of umbilical vein. Post TIPS portosystemic gradient: 15 mmHg; (D) post-TIPS and embolization ultrasound of periumbilical region shows thrombus in the periumbilical varices (white arrows).

Fig. 2. A 54-year-old male with history of alcoholic cirrhosis presented with massive lower gastrointestinal bleeding, and was hypotensive with systolic blood pressure of 50 mmHg. (A) Axial image from contrast-enhanced computed tomography (CT) shows a large superior mesenteric vein (white arrow head), cecal and ascending colon varices (white arrow); (B) coronal reformatted image from contrast enhanced CT shows cecal and ascending colon varices (white arrow), large right pleural effusion representing hepatic hydrothorax (asterisk); (C) DSA from the transjugular intrahepatic portosystemic shunt (TIPS) procedure with catheter in peripheral superior mesenteric vein shows retrograde flow in cecal and ascending colon varices (black arrows) with portosystemic shunt through retroperitoneal veins draining into inferior vena cava (white arrow). Initial portosystemic gradient: 12 mmHg; (D) image during embolization of cecal varices with multiple coils and liquid embolic agent (Onyx), balloon inflated (black arrow) in peripheral superior mesenteric vein to promote thrombosis; (E) DSA after TIPS showing antegrade flow in portal vein and non filling of cecal varices. Post TIPS portosystemic gradient: 7 mmHg. After the procedure patient became hemodynamically stable and was extubated 2 days later, with no more episodes of hematochezia.

Fig. 3. A 49-year-old female with history of primary biliary cirrhosis presented with upper gastrointestinal hemorrhage. Repeated endoscopy and banding was unable to stop hemorrhage. Balloon tamponade was done with an orogastric tube. DSA during the transjugular intrahepatic portosystemic shunt (TIPS) procedure with the catheter in the inferior mesenteric vein (black arrows) shows retrograde flow, with filling of hemorrhoidal plexus and anorectal varices (white arrow). Initial portosystemic gradient: 18 mmHg and post TIPS gradient: 6 mmHg. Post TIPS there was no retrograde flow in inferior mesenteric vein and anorectal varices. The upper gastrointestinal hemorrhage ceased, and the balloon tamponade tube was deflated at end of procedure. The patient was discharged from hospital after 5 days.

Fig. 4. Middle-aged male with uncontrolled bleeding from a recent ileostomy, with no source detected on endoscopy. (A) DSA during the transjugular intrahepatic portosystemic shunt (TIPS) procedure with the catheter in the peripheral superior mesenteric vein shows stomal varices (white arrow), a faint outline of the ileostomy bag is seen (black arrows); (B) post coil embolization (white arrows) of stomal varices, with the catheter in the superior mesenteric vein (black arrows), shows non-filling of stomal varices. The TIPS resulted in cessation of further bleeding from the stoma.

References

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Abstract
Introduction
Prevalence
Etiology and pathogenesis
Presentation and diagnosis
Specific anatomic locations
Management
Conclusion
Figure
References

Norton, ID, Andrews, JC, and Kamath, PS (1998). Management of ectopic varices. Hepatology. 28, 1154-8.
Helmy, A, Al Kahtani, K, and Al Fadda, M (2008). Updates in the pathogenesis, diagnosis and management of ectopic varices. Hepatol Int. 2, 322-34.
Kinkhabwala, M, Mousavi, A, Iyer, S, and Adamsons, R (1977). Bleeding ileal varicosity demonstrated by transhepatic portography. AJR Am J Roentgenol. 129, 514-6.
De Palma, GD, Rega, M, and Masone, S (2005). Mucosal abnormalities of the small bowel in patients with cirrhosis and portal hypertension: a capsule endoscopy study. Gastrointest Endosc. 62, 529-34.
Stephan, G, and Miething, R (1968). Rontgendiagnostik varicoser Duodenal veranderungen bei portaler Hypertension. Der Radiologe. 3, 90-5.
Hosking, SW, Smart, HL, Johnson, AG, and Triger, DR (1989). Anorectal varices, hemorrhoids and portal hypertension. Lancet. 1, 349-52.
Lebrec, D, and Benhamou, JP (1985). Ectopic varices in portal hypertension. Clin Gastroenterol. 14, 105-21.
Feldman, M, Smith, VM, and Warner, CG (1962). Varices of the colon: report of 3 cases. JAMA. 179, 729-30.
Iredale, JP, Ridings, P, McGinn, FP, and Arthur, MJ (1992). Familial and idiopathic colonic varices: an unusual cause of lower gastrointestinal haemorrhage. Gut. 33, 1285-8.
Wheeler, HB, and Warren, R (1957). Duodenal varices due to portal hypertension due to arteriovenous aneurysm. Ann Surg. 146, 229-38.
Zaman, L, Bebb, JR, Dunlop, SP, Jobling, JC, and Teahon, K (2008). Familial colonic varices: a cause of “polyposis” on barium enema. Br J Radiol. 81, 17-9.
Ryu, SH, Chang, HS, Myung, SJ, and Yang, SK (2002). Rectal varices caused by thrombosis of intra-abdominal vessels. Gastrointest Endosc. 55, 409.
Groszmann, RJ (1984). Reassessing portal venous pressure measurements. Gastroenterology. 86, 1611-4.
Tripathi, D, Helmy, A, Macbeth, K, Balata, S, Lui, HF, and Stanley, HA (2004). Ten years’ follow-up of 472 patients following transjugular intrahepatic portosystemic stent-shunt insertion at a single centre. Eur J Gastroenterol Hepatol. 16, 9-18.
Watanabe, K, Kimura, K, Matsutani, S, Ohto, M, and Okuda, K (1988). Portal hemodynamics in patients with gastric varices. A study in 230 patients with esophageal and/or gastric varices using portal vein catheterization. Gastroenterology. 95, 434-40.
Khan, MQ, Al-Momen, S, and Alghssab, A (1999). Duodenal varices causing massive lower gastrointestinal hemorrhage. Ann Saudi Med. 19, 440-3.
Khan, AA, Sarwar, S, and Alam, A (2003). Ectopic intestinal varices as a rare cause of lower gastrointestinal haemorrhage. J Coll Physicians Surg Pak. 13, 526-7.
Sato, T, Akaike, J, Toyota, J, Karino, Y, and Ohmura, T (2011). Clinicopathological features and treatment of ectopic varices with portal hypertension. Int J Hepatol. 2011, 960720.
Olusola, BF, McCashland, TM, Seemayer, TA, and Sorrell, MF (2002). Rectovesical ectopic varix intraperitoneal hemorrhage with fatal outcome. Am J Gastroenterol. 97, 504.
Lugagne, PM, Castaing, D, Conort, P, Guerrieri, M, Bousquet, O, and Chatelain, C (1992). Portal hypertension: a rare cause of hematuria. Prog Urol. 2, 294-8.
Chawla, Y, Dilawari, JB, and Katariya, S (1994). Gallbladder varices in portal vein thrombosis. AJR Am J Roentgenol. 162, 643-5.
Chu, EC, Chick, W, Hillebrand, DJ, and Hu, KQ (2002). Fatal spontaneous gallbladder variceal bleeding in a patient with alcoholic cirrhosis. Dig Dis Sci. 47, 2682-5.
Matsui, M, Kojima, A, Kakizaki, S, Nagasaka, K, Sohara, N, and Sato, K (2006). Ectopic varices in a right diaphragm that ruptured into the pleural cavity. Acta Med Okayama. 60, 229-32.
Ramchandran, TM, John, A, Ashraf, SS, Moosabba, MS, Nambiar, PV, and Shobana Devi, R (2000). Hemoperitoneum following rupture of ectopic varix along splenorenal ligament in extrahepatic portal vein obstruction. Indian J Gastroenterol. 19, 91.
Lim, LG, Lee, YM, Tan, L, Chang, S, and Lim, SG (2009). Percutaneous paraumbilical embolization as an unconventional and successful treatment for bleeding jejunal varices. World J Gastroenterol. 15, 3823-6.
Hekmat, H, Al-toma, A, Mallant, MP, Mulder, CJ, and Jacobs, MA (2007). Endoscopic N-butyl-2-cyanoacrylate (Histoacryl) obliteration of jejunal varices by using the double balloon enteroscope. Gastrointest Endosc. 65, 350-2.
Dhiman, RK, Saraswat, VA, Choudhuri, G, Sharma, BC, Pandey, R, and Naik, SR (1999). Endosonographic, endoscopic and histologic evaluation of alterations in the rectal venous system in patients with portal hypertension. Gastrointest Endosc. 49, 218-27.
Palazzo, L, Hochain, P, Helmer, C, Cuillerier, E, Landi, B, and Roseau, G (2000). Biliary varices on endoscopic ultrasonography: clinical presentation and outcome. Endoscopy. 32, 520-4.
Komatsuda, T, Ishida, H, Konno, K, Hamashima, Y, Ohnami, Y, and Naganuma, H (1998). Color Doppler findings of gastrointestinal varices. Abdom Imaging. 23, 45-50.
Sato, T, Yamazaki, K, Toyota, J, Karino, Y, Ohmura, T, and Akaike, J (2007). Diagnosis of rectal varices via color Doppler ultrasonography. Am J Gastroenterol. 102, 2253-8.
Gulati, G, Pawa, S, Chowdhary, V, Kumar, N, and Mittal, SK (2003). Colour Doppler flow imaging findings in portal biliopathy. Trop Gastroenterol. 24, 116-9.
Weishaupt, D, Pfammatter, T, Hilfiker, PR, Wolfensberger, U, and Marincek, B (2002). Detecting bleeding duodenal varices with multislice helical CT. AJR Am J Roentgenol. 178, 399-401.
Jain, TP, Gulati, MS, Makharia, GK, and Paul, SB (2005). Case of the season: detection of duodenal varices by CT enteroclysis. Semin Roentgenol. 40, 204-6.
Smith, TR (1994). CT demonstration of ascending colon varices. Clin Imaging. 18, 4-6.
Bykov, S, Becker, A, Koltun, L, Yudko, E, and Garty, I (2005). Massive bleeding from jejunal varices in a patient with thalassemia major detected by TC-99m red blood cell scintigraphy. Clin Nucl Med. 30, 457-9.
Handschin, AE, Weber, M, Weishaupt, D, Fried, M, and Clavien, PA (2002). Contrast-enhanced three-dimensional magnetic resonance angiography for visualization of ectopic varices. Dis Colon Rectum. 45, 1541-4.
Amin, R, Alexis, R, and Korzis, J (1985). Fatal ruptured duodenal varix: a case report and review of literature. Am J Gastroenterol. 80, 13-8.
Brown, KM, Kaplan, MM, and Donowitz, M (1985). Extrahepatic portal venous thrombosis: frequent recognition of associated diseases. J Clin Gastroenterol. 7, 153-9.
Grendell, JH, and Ockner, RK (1982). Mesenteric venous thrombosis. Gastroenterology. 82, 358-72.
Wu, WC, Wang, LY, Yu, FJ, Wang, WM, Chen, SC, and Chuang, WL (2002). Bleeding duodenal varices after gastroesophageal varices ligation: a case report. Kaohsiung J Med Sci. 18, 578-81.
Hashizume, M, Tanoue, K, and Ohta, M (1993). Vascular anatomy of duodenal varices: angiographic and histopathological assessments. Am J Gastroenterol. 88, 1942-5.
Jonnalagadda, SS, Quiason, S, and Smith, OJ (1998). Successful therapy of bleeding duodenal varices by TIPS after failure of sclerotherapy. Am J Gastroenterol. 93, 272-4.
Cappell, MS, and Price, JB (1987). Characterization of the syndrome of small and large intestinal variceal bleeding. Dig Dis Sci. 32, 422-7.
Johansen, K, Bardin, J, and Orloff, MJ (1980). Massive bleeding from hemorrhoidal varices in portal hypertension. JAMA. 244, 2084-5.
Hamlyn, AN, Morris, JS, Lunzer, MR, Puritz, H, and Dick, R (1974). Portal hypertension with varices in unusual sites. Lancet. 2, 1531-4.
Weisner, RH, LaRusso, NF, and Dozois, RR (1986). Peristomal varices after proctocolectomy in patients with primary sclerosing cholangitis. Gastroenterology. 90, 316-22.
Samaraweera, RN, Feldman, L, Widrich, WC, Waltman, A, Steinberg, F, and Greenfield, A (1989). Stomal varices: percutaneous transhepatic embolization. Radiology. 170, 779-82.
Roberts, PL, Martin, FM, Schoetz, DJ, Murray, JJ, Coller, JA, and Veidenheimer, MC (1990). Bleeding stomal varices. The role of local treatment. Dis Colon Rectum. 33, 547-9.
Akselrod, DG, Wong, C, and Keating, DP (2012). Spleno-parametrial ectopic varices: an unusual portosystemic shunt in portal hypertension. Obstet Gynecol. 119, 455-9.
Krishna, S, Rose, J, Jambhekar, K, Olden, K, and Aduli, F (2009). Cirrhosis of liver and an unusual ectopic site of portosystemic shunt: left adnexal venous varix presenting with hematuria. Am J Gastroenterol. 104, 2365-6.
Kreek, MJ, Raziano, JV, Hardy, RE, and Jeffries, GH (1967). Portal hypertension with bleeding vaginal varices. Ann Intern Med. 66, 756-9.
Assis, DN, Pollak, J, Schilsky, ML, and Emre, S (2012). Successful treatment of a bleeding umbilical varix by percutaneous umbilical vein embolization with sclerotherapy. J Clin Gastroenterol. 46, 115-8.
Bahner, DR, and Holland, RW (1992). Exsanguinating hemorrhage from a caput medusae: cutaneous variceal bleeding. J Emerg Med. 10, 19-23.
Schmitz, RJ, Sharma, P, Badr, AS, Qamar, MT, and Weston, AP (2001). Incidence and management of esophageal stricture formation, ulcer bleeding, perforation and massive hematoma formation from sclerotherapy versus band ligation. Am J Gastroenterol. 96, 437-41.
Seewald, S, Seitz, U, Yang, AM, and Soehendra, N (2001). Variceal bleeding and portal hypertension: still a therapeutic challenge?. Endoscopy. 33, 126-39.
Tajiri, T, Onda, M, Yoshida, H, Mamada, Y, Taniai, N, and Umehara, M (2002). Endoscopic scleroligation is a superior new technique for preventing recurrence of esophageal varices. J Nihon Med Sch. 69, 160-4.
Akazawa, Y, Murata, I, Yamao, T, Yamakawa, M, Kawano, Y, and Nomura, N (2003). Successful management of bleeding duodenal varices by endoscopic variceal ligation and balloon-occluded retrograde transvenous obliteration. Gastrointest Endosc. 58, 794-7.
Yoshida, Y, Imai, Y, Nishikawa, M, Nakatukasa, M, Kurokawa, M, and Shibata, K (1997). Successful endoscopic injection sclerotherapy with N-butyl-2-cyanoacrylate following the recurrence of bleeding soon after endoscopic ligation for ruptured duodenal varices. Am J Gastroenterol. 92, 1227-9.
Chen, WC, Hou, MC, Lin, HC, Chang, FY, and Lee, SD (2000). An endoscopic injection with N-butyl-2-cyanoacrylate used for colonic variceal bleeding: a case report and review of the literature. Am J Gastroenterol. 95, 540-2.
Shudo, R, Yazaki, Y, Sakurai, S, Uenishi, H, Yamada, H, and Sugawara, K (2001). Combined endoscopic variceal ligation and sclerotherapy for bleeding rectal varices associated with primary biliary cirrhosis: a case showing a long-lasting favorable response. Gastrointest Endosc. 53, 661-5.
Wolfsen, HC, Kozarek, RA, Bredfeldt, JE, Fenster, LF, and Brubacher, LL (1990). The role of endoscopic injection sclerotherapy in the management of bleeding peristomal varices. Gastrointest Endosc. 36, 472-4.
Vangeli, M, Patch, D, Terreni, N, Tibballs, J, Watkinson, A, and Davies, N (2004). Bleeding ectopic varices?treatment with transjugular intrahepatic portosystemic shunt (TIPS) and embolisation. J Hepatol. 41, 560-6.
Papatheodoridis, GV, Goulis, J, Leandro, G, Patch, D, and Burroughs, AK (1999). Transjugular intrahepatic portosystemic shunt compared with endoscopic treatment for prevention of variceal rebleeding: a meta-analysis. Hepatology. 30, 612-22.
Garcia-Pagan, JC, Caca, K, Bureau, C, Laleman, W, Appenrodt, B, and Luca, A (2010). Early use of TIPS in patients with cirrhosis and variceal bleeding. N Engl J Med. 362, 2370-9.
Rossle, M, Siegerstetter, V, Olschewski, M, Ochs, A, Berger, E, and Haag, K (2001). How much reduction in portal pressure is necessary to prevent variceal rebleeding? A longitudinal study in 225 patients with transjugular intrahepatic portosystemic shunts. Am J Gastroenterol. 96, 3379-83.
Haskal, ZJ, Scott, M, Rubin, RA, and Cope, C (1994). Intestinal varices: treatment with the transjugular intrahepatic portosystemic shunt. Radiology. 191, 183-7.
Ory, G, Spahr, L, Megevand, JM, Becker, C, and Hadengue, A (2001). The longterm efficacy of the intrahepatic portosystemic shunt (TIPS) for the treatment of bleeding anorectal varices in cirrhosis. A case report and review of the literature. Digestion. 64, 261-4.
Ryu, RK, Nemcek, AA, and Chrisman, HB (2000). Treatment of stomal variceal hemorrhage with TIPS: case report and review of the literature. Cardiovasc Intervent Radiol. 23, 301-3.
Zimmerman, G, Smith, DC, Taylor, FC, and Hadley, HR (1994). Recurrent urinary conduit bleeding in a patient with portal hypertension: management with a transjugular intrahepatic portosystemic shunt. Urology. 43, 748-51.
Hassoun, Z, Pomier-Layrargues, G, Lafortune, M, Perreault, P, Gianfelice, D, and Bui, B (2000). Umbilical hemorrhage from a cutaneous varix treated by transjugular intrahepatic portosystemic shunt (TIPS). Am J Gastroenterol. 95, 2139-40.
Park, KS, Kim, YH, Choi, JS, Hwang, JS, Kwon, JH, and Jang, BK (2006). Therapeutic efficacy of balloon-occluded retrograde transvenous obliteration in patients with gastric variceal bleeding. Korean J Gastroenterol. 47, 370-8.
Choi, YH, Yoon, CJ, Park, JH, Chung, JW, Kwon, JW, and Choi, GM (2003). Balloon-occluded retrograde transvenous obliteration for gastric variceal bleeding: its feasibility compared with transjugular intrahepatic portosystemic shunt. Korean J Radiol. 4, 109-16.
Kim, MJ, Jang, BK, Chung, WJ, Hwang, JS, and Kim, YH (2012). Duodenal variceal bleeding after balloon-occluded retrograde transvenous obliteration: treatment with transjugular intrahepatic portosystemic shunt. World J Gastroenterol. 18, 2877-80.
Takamura, K, Miyake, H, Mori, H, Terashima, Y, Ando, T, and Fujii, M (2005). Balloon occluded retrograde transvenous obliteration and percutaneous transhepatic obliteration for ruptured duodenal varices after operation for rectal cancer with multiple liver metastasis: report of a case. J Med Invest. 52, 212-7.
Sonomura, T, Horihata, K, Yamahara, K, Dozaiku, T, Toyonaga, T, and Hiroka, T (2003). Ruptured duodenal varices successfully treated with balloon-occluded retrograde transvenous obliteration: usefulness of microcatheters. AJR Am J Roentgenol. 181, 725-7.
Hashimoto, N, Akahoshi, T, and Yoshida, D (2010). The efficacy of balloon-occluded retrograde transvenous obliteration on small intestinal variceal bleeding. Surgery. 148, 145-50.
Anan, A, Irie, M, Watanabe, H, Sohda, T, Iwata, K, and Suzuki, N (2006). Colonic varices treated by balloon-occluded retrograde transvenous obliteration in a cirrhotic patient with encephalopathy: a case report. Gastrointest Endosc. 63, 880-4.
Minami, S, Okada, K, Matsuo, M, Kamohara, Y, Sakamoto, I, and Kanematsu, T (2007). Treatment of bleeding stomal varices by balloon-occluded retrograde transvenous obliteration. J Gastroenterol. 42, 91-5.
Ono, S, Irie, T, Kuramochi, M, Kamoshida, T, Hirai, S, and Oka, Y (2007). Successful treatment of mesenteric varices with balloon-occluded retrograde transvenous obliteration via an abdominal wall vein. J Vasc Interv Radiol. 18, 1033-5.
Smith-Laing, G, Scott, J, Long, RG, and Sherlock, S (1981). Role of percutaneous transhepatic obliteration of varices in the management of bleeding from gastroesophageal varices. Gastroenterology. 80, 1031-6.
Dharancy, S, Sergent, G, Bulois, P, Bonnal, JL, Golup, G, and Mauroy, B (2000). Bleeding stomal varices treated with embolization and transjugular portosystemic shunt. Gastroenterol Clin Bio. 24, 232-4.
Sakai, M, Nakao, A, Kaneko, T, Takeda, S, Inoue, S, and Yagi, Y (2005). Transhepatic portal venous angioplasty with stenting for bleeding jejunal varices. Hepatogastroenterology. 52, 749-52.
Naidu, SG, Castle, EP, Kriegshauser, JS, and Huettl, EA (2010). Direct percutaneous embolization of bleeding stomal varices. Cardiovasc Intervent Radiol. 33, 201-4.
Ohta, T, Kitagawa, T, Sohma, M, Mutoh, E, Takeda, S, and Uekita, Y (1991). Duodenal varices successfully treated with percutaneous transhepatic obliteration. Hokkaido Igaku Zasshi. 66, 79-85.
Okazaki, H, Higuchi, K, Shiba, M, Nakamura, S, Wada, T, and Yamamori, K (2006). Successful treatment of giant rectal varices by modified percutaneous transhepatic obliteration with sclerosant: report of a case. World J Gastroenterol. 12, 5408-11.
Chikamori, F, Kuniyoshi, N, Kagiyama, S, Kawashima, T, Shibuya, S, and Takase, Y (2007). Role of percutaneous transhepatic obliteration for special types of varices with portal hypertension. Abdom Imaging. 32, 92-5.
Sato, T (2010). Transabdominal color Doppler ultrasonography for the diagnosis of small intestinal and vesical varices in a patient successfully treated with percutaneous transhepatic obliteration. Clin J Gastroenterol. 3, 214-8.
Wolff, M, and Hirner, A (2003). Current state of portosystemic shunt surgery. Langenbecks Arch Surg. 388, 141-9.
Goyal, N, Singhal, D, Gupta, S, Soin, AS, and Nundy, S (2007). Transabdominal gastroesophageal devascularization without transaction for bleeding varices: results and indicators of prognosis. J Gastroenterol Hepatol. 22, 47-50.
Sato, Y, Yokoyama, N, Suzuki, S, Tani, T, Nomoto, M, and Hatakeyama, K (2002). Double selective shunting for esophagogastric and rectal varices in portal hypertension due to congenital hepatic polycystic disease. Hepatogastroenterology. 49, 1528-30.
D’Cruz, AJ, Kamath, PS, Ramachandra, C, and Jalihal, A (1995). Non-conventional portosystemic shunts in children with extrahepatic portal vein obstruction. Acta Pediatr Jpn. 37, 17-20.
McAlister, VC, and Al-Saleh, NA (2005). Duodenal dearterialization and stapling for severe hemorrhage from duodenal varices with portal vein thrombosis. Am J Surg. 189, 49-52.
Ueda, J, Yoshida, H, and Mamada, Y (2006). Successful emergency enterectomy for bleeding ileal varices in a patient with liver cirrhosis. J Nihon Med Sch. 73, 221-5.
Detry, RJ, Kartheuser, A, and Moisse, R (1996). Idiopathic nonfamilial rectal and colonic varices requiring sigmoidorectal resection and coloanal anastomosis. Eur J Gastroenterol Hepatol. 8, 1023-6.
Botterill, ID, Jayne, DG, Snelling, AP, and Ambrose, NS (2002). Correction of symptomatic ano-rectal varices with circumferential stapled anoplasty. Colorectal Dis. 4, 217.
Takase, Y, Shibuya, S, Chikamori, F, Orii, K, and Iwasaki, Y (1990). Recurrence factors studied by percutaneous transhepatic portography before and after endoscopic sclerotherapy for esophageal varices. Hepatology. 11, 348-52.
Arai, H, Abe, T, Takagi, H, and Mori, M (2006). Efficacy of balloon-occluded retrograde transvenous obliteration, percutaneous transhepatic obliteration and combined techniques for the management of gastric fundal varices. World J Gastroenterol. 12, 3866-73.